PRAK, a novel protein kinase regulated by the p38 MAP kinase

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PRAK, a novel protein kinase regulated by the p38 MAP kinase.

We have identified and cloned a novel serine/ threonine kinase, p38-regulated/activated protein kinase (PRAK). PRAK is a 471 amino acid protein with 20-30% sequence identity to the known MAP kinase-regulated protein kinases RSK1/2/3, MNK1/2 and MAPKAP-K2/3. PRAK was found to be expressed in all human tissues and cell lines examined. In HeLa cells, PRAK was activated in response to cellular stre...

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ژورنال

عنوان ژورنال: The EMBO Journal

سال: 1998

ISSN: 1460-2075

DOI: 10.1093/emboj/17.12.3372